7uls
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Recombinant muscarinic toxin alpha== | |
| - | + | <StructureSection load='7uls' size='340' side='right'caption='[[7uls]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7uls]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uls OCA], [https://pdbe.org/7uls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uls RCSB], [https://www.ebi.ac.uk/pdbsum/7uls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uls ProSAT]</span></td></tr> |
| - | [[Category: Lei | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/3SIMA_DENPO 3SIMA_DENPO] Selectively binds with high-affinity to the a2B-adrenoceptor subtype (ADRA2B) (PubMed:20466015). The toxin reversibly binds to ADRA2B, and its mode of inhibition is non-competitive (PubMed:20466015). The toxin has also been described to bind with high affinity to all muscarinic receptor subtypes (Ki=23 nM (on CHRM1), Ki=44 nM (on CHRM2), Ki=3 nM (on CHRM3), Ki=5 nM (on CHRM4), and Ki=8 nM (on CHRM5)) but no other data support these affinity values (PubMed:8536706).<ref>PMID:10978757</ref> <ref>PMID:20466015</ref> <ref>PMID:21557730</ref> <ref>PMID:8536706</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dendroaspis polylepis polylepis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen L]] | ||
| + | [[Category: Lei X]] | ||
| + | [[Category: Xu J]] | ||
Current revision
Recombinant muscarinic toxin alpha
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