7uv2
From Proteopedia
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(New page: '''Unreleased structure''' The entry 7uv2 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Ana o 1 Leader Sequence Residues 82-132== | |
| + | <StructureSection load='7uv2' size='340' side='right'caption='[[7uv2]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7uv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anacardium_occidentale Anacardium occidentale]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UV2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uv2 OCA], [https://pdbe.org/7uv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uv2 RCSB], [https://www.ebi.ac.uk/pdbsum/7uv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uv2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8L5L5_ANAOC Q8L5L5_ANAOC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. Peptide microarrays were used to identify immunoglobulin E (IgE) epitopes from the N-terminus of the vicilin allergens Ara h 1, Ana o 1, Jug r 2, and Pis v 3 using serum from three patient diagnosis groups: monoallergic to either peanuts or cashew/pistachio, or dual allergic. IgE binding peptides were highly prevalent in the VBP domains AH1.1, AO1.1, JR2.1, and PV3.1, but not in AO1.2, JR2.2, JR2.3, and PV3.2 nor the unstructured regions. The IgE profiles did not correlate with diagnosis group. The structure of the VBPs from cashew and pistachio was solved using solution-NMR. Comparisons of structural features suggest that the VBP scaffold from peanuts and tree-nuts can support cross-reactivity. This may help understand comorbidity and cross-reactivity despite a distant evolutionary origin. | ||
| - | + | Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides.,Foo ACY, Nesbit JB, Gipson SAY, DeRose EF, Cheng H, Hurlburt BK, Kulis MD, Kim EH, Dreskin SC, Mustafa S, Maleki SJ, Mueller GA J Agric Food Chem. 2023 Feb 15;71(6):2990-2998. doi: 10.1021/acs.jafc.2c07061. , Epub 2023 Feb 2. PMID:36728846<ref>PMID:36728846</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7uv2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Anacardium occidentale]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: DeRose EF]] | ||
| + | [[Category: Foo ACY]] | ||
| + | [[Category: Mueller GA]] | ||
Current revision
Ana o 1 Leader Sequence Residues 82-132
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