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7uvf
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7uvf is ON HOLD Authors: Yu, C., Davies, C., Koerber, J.T., Williams, S. Description: Crystal structure of ZED8 Fab complex with CD8 alpha [[Catego...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of ZED8 Fab complex with CD8 alpha== | |
| + | <StructureSection load='7uvf' size='340' side='right'caption='[[7uvf]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7uvf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UVF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uvf OCA], [https://pdbe.org/7uvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uvf RCSB], [https://www.ebi.ac.uk/pdbsum/7uvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uvf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN] Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:[https://omim.org/entry/608957 608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. | ||
| - | + | ==See Also== | |
| - | + | *[[CD8 3D structures|CD8 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Koerber | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Davies C]] |
| - | [[Category: | + | [[Category: Koerber JT]] |
| + | [[Category: Williams S]] | ||
| + | [[Category: Yu C]] | ||
Current revision
Crystal structure of ZED8 Fab complex with CD8 alpha
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