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7xq0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7xq0 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of hSLC19A1+3'3'-CDA== | |
| - | + | <StructureSection load='7xq0' size='340' side='right'caption='[[7xq0]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7xq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XQ0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xq0 OCA], [https://pdbe.org/7xq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xq0 RCSB], [https://www.ebi.ac.uk/pdbsum/7xq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xq0 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/S19A1_HUMAN S19A1_HUMAN] Methotrexate dose selection. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S19A1_HUMAN S19A1_HUMAN] Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31511694, PubMed:31126740, PubMed:32276275). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31511694, PubMed:31126740). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31511694, PubMed:31126740). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803).<ref>PMID:10787414</ref> <ref>PMID:14609557</ref> <ref>PMID:15337749</ref> <ref>PMID:16115875</ref> <ref>PMID:22554803</ref> <ref>PMID:31126740</ref> <ref>PMID:31511694</ref> <ref>PMID:32276275</ref> <ref>PMID:7615551</ref> <ref>PMID:7641195</ref> <ref>PMID:7826387</ref> <ref>PMID:9041240</ref> <ref>PMID:9767079</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gao A]] | ||
| + | [[Category: Gao P]] | ||
| + | [[Category: Sun PP]] | ||
| + | [[Category: Zhang LG]] | ||
| + | [[Category: Zhang QX]] | ||
| + | [[Category: Zhang XY]] | ||
| + | [[Category: Zhu YL]] | ||
Current revision
Structure of hSLC19A1+3'3'-CDA
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Categories: Homo sapiens | Large Structures | Gao A | Gao P | Sun PP | Zhang LG | Zhang QX | Zhang XY | Zhu YL
