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3ncl

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Current revision (09:13, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3ncl' size='340' side='right'caption='[[3ncl]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
<StructureSection load='3ncl' size='340' side='right'caption='[[3ncl]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ncl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NCL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ncl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NCL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCZ:PHENYL+(4-CARBAMIMIDOYLBENZYL)PHOSPHONATE'>CCZ</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ST14, PRSS14, SNC19, TADG15 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCZ:PHENYL+(4-CARBAMIMIDOYLBENZYL)PHOSPHONATE'>CCZ</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Matriptase Matriptase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.109 3.4.21.109] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ncl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ncl OCA], [https://pdbe.org/3ncl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ncl RCSB], [https://www.ebi.ac.uk/pdbsum/3ncl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ncl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ncl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ncl OCA], [https://pdbe.org/3ncl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ncl RCSB], [https://www.ebi.ac.uk/pdbsum/3ncl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ncl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[https://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
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[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[https://omim.org/entry/610765 610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
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[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Matriptase]]
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[[Category: Brown C]]
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[[Category: Brown, C]]
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[[Category: Egea P]]
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[[Category: Egea, P]]
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[[Category: Ray M]]
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[[Category: Ray, M]]
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[[Category: Benzamidine]]
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[[Category: Hydrolase]]
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[[Category: Phosphonate]]
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[[Category: Proteinase-inhibitor complex]]
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[[Category: Serine endopeptidase]]
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[[Category: Serine proteinase]]
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Current revision

Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor

PDB ID 3ncl

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