3o16

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Current revision (10:02, 14 February 2024) (edit) (undo)
 
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<StructureSection load='3o16' size='340' side='right'caption='[[3o16]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3o16' size='340' side='right'caption='[[3o16]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3o16]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O16 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3o16]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O16 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3o15|3o15]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU38290, ipa-26d, thiC, thiE, ywbK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiamine-phosphate_diphosphorylase Thiamine-phosphate diphosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.3 2.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o16 OCA], [https://pdbe.org/3o16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o16 RCSB], [https://www.ebi.ac.uk/pdbsum/3o16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o16 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o16 OCA], [https://pdbe.org/3o16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o16 RCSB], [https://www.ebi.ac.uk/pdbsum/3o16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o16 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/THIE_BACSU THIE_BACSU]] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Is also able to use the 2-methoxy analog MeO-HMP-PP, as substrate in vitro, but not the 2-trifluoromethyl analog CF(3)-HMP-PP.<ref>PMID:9139923</ref> <ref>PMID:11513588</ref>
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[https://www.uniprot.org/uniprot/THIE_BACSU THIE_BACSU] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Is also able to use the 2-methoxy analog MeO-HMP-PP, as substrate in vitro, but not the 2-trifluoromethyl analog CF(3)-HMP-PP.<ref>PMID:9139923</ref> <ref>PMID:11513588</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Vibrio subtilis ehrenberg 1835]]
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[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thiamine-phosphate diphosphorylase]]
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[[Category: Abdelwahed S]]
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[[Category: Abdelwahed, S]]
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[[Category: Begley TP]]
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[[Category: Begley, T P]]
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[[Category: Ealick SE]]
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[[Category: Ealick, S E]]
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[[Category: Hanes JW]]
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[[Category: Hanes, J W]]
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[[Category: Hazra A]]
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[[Category: Hazra, A]]
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[[Category: Ishida K]]
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[[Category: Ishida, K]]
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[[Category: Mahanta N]]
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[[Category: Mahanta, N]]
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[[Category: McCulloch KM]]
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[[Category: McCulloch, K M]]
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[[Category: Thiamin biosynthesis]]
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[[Category: Tim barrel]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Bacillus subtilis Thiamin Phosphate Synthase K159A

PDB ID 3o16

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