3o7v

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<StructureSection load='3o7v' size='340' side='right'caption='[[3o7v]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3o7v' size='340' side='right'caption='[[3o7v]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3o7v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O7V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3o7v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O7V FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3o3i|3o3i]], [[3o6e|3o6e]], [[3o7x|3o7x]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HIWI, Piwi-like protein 1, PIWIL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7v OCA], [https://pdbe.org/3o7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o7v RCSB], [https://www.ebi.ac.uk/pdbsum/3o7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o7v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o7v OCA], [https://pdbe.org/3o7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o7v RCSB], [https://www.ebi.ac.uk/pdbsum/3o7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o7v ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/PIWL1_HUMAN PIWL1_HUMAN]] Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.<ref>PMID:12037681</ref> <ref>PMID:14749716</ref> <ref>PMID:16287078</ref>
 
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ma, J B]]
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[[Category: Ma J-B]]
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[[Category: Patel, D J]]
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[[Category: Patel DJ]]
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[[Category: Simanshu, D K]]
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[[Category: Simanshu DK]]
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[[Category: Tian, Y]]
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[[Category: Tian Y]]
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[[Category: Hili]]
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[[Category: Hiwi1]]
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[[Category: Paz domain]]
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[[Category: Pi-rna]]
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[[Category: Piwi]]
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[[Category: Rna binding protein]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Rna silencing]]
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Current revision

Crystal Structure of human Hiwi1 (V361M) PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OCH3 at its 3'-end

PDB ID 3o7v

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OCA

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