TrkB tyrosine kinase receptor
From Proteopedia
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<StructureSection load='1hcf' size='340' side='right' caption='Human TrkB (yellow and pink) complex with neurotrophin-4/5 (cyan and green) and sulfate ions (PDB code [[1hcf]])' scene='80/805008/Cv/1'> | <StructureSection load='1hcf' size='340' side='right' caption='Human TrkB (yellow and pink) complex with neurotrophin-4/5 (cyan and green) and sulfate ions (PDB code [[1hcf]])' scene='80/805008/Cv/1'> | ||
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== Function == | == Function == | ||
| - | '''TrkB tyrosine kinase receptor''' (TrkB) or '''BDNF/NT-3 growth factors receptor''' is part of the Trk [[tyrosine kinase receptors]] family which includes '''TrkA''' or ([[High affinity nerve growth factor receptor]]) and '''TrkC''' or '''NT-3 growth factor receptor''' which are responsible for mediating the trophic effects of the nerve growth factor family of neurotrophins. TrkB is activated by Brain-Derived Neurotrophic Factor (BDNF) and neurotrophin-4 (NT4)<ref>PMID:7852993</ref>. TrkB pathway is vital in neural development and maintenance through differentiation and neurogenesis. See also [[Neurotrophin]] | + | '''TrkB tyrosine kinase receptor''' (TrkB) or '''BDNF/NT-3 growth factors receptor''' is part of the Trk [[tyrosine kinase receptors]] family which includes '''TrkA''' or ([[High affinity nerve growth factor receptor]]) and '''TrkC''' or '''NT-3 growth factor receptor''' which are responsible for mediating the trophic effects of the nerve growth factor family of neurotrophins. |
| + | TrkB is activated by Brain-Derived Neurotrophic Factor (BDNF) and neurotrophin-4 (NT4)<ref>PMID:7852993</ref>. TrkB pathway is vital in neural development and maintenance through differentiation and neurogenesis. See also [[Neurotrophin]] | ||
== Relevance == | == Relevance == | ||
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<scene name='80/805008/Cv/6'>Structure of the TrkB-d5:NT-4/5 Complex, comprising one homodimer of NT-4/5 bound to two monomers of TrkB-d5</scene>. TrkB and neutrotrophin-4/5 interact via a <scene name='80/805008/Cv/7'>specificity interaction site</scene> and via a <scene name='80/805008/Cv/8'>conserved interaction site</scene><ref>PMID:11738045</ref>. | <scene name='80/805008/Cv/6'>Structure of the TrkB-d5:NT-4/5 Complex, comprising one homodimer of NT-4/5 bound to two monomers of TrkB-d5</scene>. TrkB and neutrotrophin-4/5 interact via a <scene name='80/805008/Cv/7'>specificity interaction site</scene> and via a <scene name='80/805008/Cv/8'>conserved interaction site</scene><ref>PMID:11738045</ref>. | ||
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| - | </StructureSection> | ||
==3D structures of TrkB tyrosine kinase receptor== | ==3D structures of TrkB tyrosine kinase receptor== | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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