7uze

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(New page: '''Unreleased structure''' The entry 7uze is ON HOLD Authors: Vallese, F., Kim, K., Yen, L.Y., Johnston, J.D., Noble, A.J., Cali, T., Clarke, O.B. Description: Band 3-Glycophorin A com...)
Current revision (04:47, 8 September 2022) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7uze is ON HOLD
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==Erythrocyte ankyrin-1 complex class 2 local refinement of AQP1 (C4 symmetry applied)==
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<StructureSection load='7uze' size='340' side='right'caption='[[7uze]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7uze]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UZE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uze OCA], [https://pdbe.org/7uze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uze RCSB], [https://www.ebi.ac.uk/pdbsum/7uze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uze ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/AQP1_HUMAN AQP1_HUMAN]] Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.<ref>PMID:1373524</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhesus glycoproteins remains unknown. Here we present structures of ankyrin-1 complexes purified from human erythrocytes. We reveal the architecture of a core complex of ankyrin-1, the Rhesus proteins RhAG and RhCE, the band 3 anion exchanger, protein 4.2, glycophorin A and glycophorin B. The distinct T-shaped conformation of membrane-bound ankyrin-1 facilitates recognition of RhCE and, unexpectedly, the water channel aquaporin-1. Together, our results uncover the molecular details of ankyrin-1 association with the erythrocyte membrane, and illustrate the mechanism of ankyrin-mediated membrane protein clustering.
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Authors: Vallese, F., Kim, K., Yen, L.Y., Johnston, J.D., Noble, A.J., Cali, T., Clarke, O.B.
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Architecture of the human erythrocyte ankyrin-1 complex.,Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB Nat Struct Mol Biol. 2022 Jul;29(7):706-718. doi: 10.1038/s41594-022-00792-w., Epub 2022 Jul 14. PMID:35835865<ref>PMID:35835865</ref>
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Description: Band 3-Glycophorin A complex, outward facing
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Vallese, F]]
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<div class="pdbe-citations 7uze" style="background-color:#fffaf0;"></div>
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[[Category: Johnston, J.D]]
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== References ==
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[[Category: Yen, L.Y]]
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<references/>
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[[Category: Kim, K]]
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__TOC__
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[[Category: Clarke, O.B]]
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</StructureSection>
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[[Category: Cali, T]]
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[[Category: Homo sapiens]]
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[[Category: Noble, A.J]]
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[[Category: Large Structures]]
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[[Category: Cali T]]
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[[Category: Clarke OB]]
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[[Category: Johnston JD]]
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[[Category: Kim K]]
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[[Category: Noble AJ]]
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[[Category: Vallese F]]
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[[Category: Yen LY]]

Current revision

Erythrocyte ankyrin-1 complex class 2 local refinement of AQP1 (C4 symmetry applied)

PDB ID 7uze

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