7zic
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor== | |
| - | + | <StructureSection load='7zic' size='340' side='right'caption='[[7zic]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zic]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZIC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YG:~{N}-[(4-methoxyphenyl)methyl]-4-(pyridin-4-ylmethyl)aniline'>5YG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zic OCA], [https://pdbe.org/7zic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zic RCSB], [https://www.ebi.ac.uk/pdbsum/7zic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zic ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Levy | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CP125_MYCTU CP125_MYCTU] Catalyzes the C-27 hydroxylation of cholest-4-en-3-one and cholesterol and subsequently oxidizes the alcohol of the former to the cholest-4-en-3-one-27-oic acid via the aldehyde intermediate. Not required to incorporate the cholesterol side-chain carbon atoms into cellular lipids.<ref>PMID:19846551</ref> <ref>PMID:20545858</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Kavanagh M]] | ||
| + | [[Category: Levy C]] | ||
| + | [[Category: Snee M]] | ||
Current revision
Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
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