7zu4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human Parechovirus 1 2A protein lacking the C-terminal oligomerisation helix== | |
| - | + | <StructureSection load='7zu4' size='340' side='right'caption='[[7zu4]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zu4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_parechovirus_1 Human parechovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZU4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zu4 OCA], [https://pdbe.org/7zu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zu4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zu4 ProSAT]</span></td></tr> |
| - | [[Category: Perrakis | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/POLG_HPE1H POLG_HPE1H] Capsid proteins VP0, VP2, VP3 form a closed capsid enclosing the viral positive strand RNA genome. Capsid proteins interact with host alpha-V/beta-3 integrin heterodimer to provide virion attachment target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:11160695</ref> Protein 2A: Is not a protease. Protein 2B: Affects membrane integrity and cause an increase in membrane permeability. Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity). Protein 3A, via its hydrophobic domain, serves as membrane anchor. Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity). RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[PROSITE-ProRule:PRU00539] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human parechovirus 1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Perrakis A]] | ||
| + | [[Category: Von Castelmur E]] | ||
Current revision
Crystal Structure of Human Parechovirus 1 2A protein lacking the C-terminal oligomerisation helix
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