1f0j

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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B

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-[[Image:1f0j.gif|left|200px]]<br />
-<applet load="1f0j" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1f0j, resolution 1.77&Aring;" />
-'''CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B'''<br />
-==Overview==
+==CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B==
-Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth, and, differentiation. These molecules are degraded by a family of enzymes known, as phosphodiesterases, which serve a critical function by regulating the, intracellular concentration of cyclic nucleotides. We have determined the, three-dimensional structure of the catalytic domain of phosphodiesterase, 4B2B to 1.77 angstrom resolution. The active site has been identified and, contains a cluster of two metal atoms. The structure suggests the, mechanism of action and basis for specificity and will provide a framework, for structure-assisted drug design for members of the phosphodiesterase, family.
+<StructureSection load='1f0j' size='340' side='right'caption='[[1f0j]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1f0j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0J FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0j OCA], [https://pdbe.org/1f0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0j RCSB], [https://www.ebi.ac.uk/pdbsum/1f0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0j ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/1f0j_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f0j ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-F0J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, MG and ARS as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1F0J OCA].
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
-==Reference==
+<references/>
-Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity., Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT, Science. 2000 Jun 9;288(5472):1822-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10846163 10846163]
+__TOC__
-[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Hassell, A.M.]]
+[[Category: Hassell AM]]
-[[Category: Holmes, W.D.]]
+[[Category: Holmes WD]]
-[[Category: Ke, H.]]
+[[Category: Ke H]]
-[[Category: Lambert, M.H.]]
+[[Category: Lambert MH]]
-[[Category: Luther, M.A.]]
+[[Category: Luther MA]]
-[[Category: Milburn, M.V.]]
+[[Category: Milburn MV]]
-[[Category: Nolte, R.T.]]
+[[Category: Nolte RT]]
-[[Category: Rocque, W.J.]]
+[[Category: Rocque WJ]]
-[[Category: Vanderwall, D.]]
+[[Category: Vanderwall D]]
-[[Category: Xu, R.X.]]
+[[Category: Xu RX]]
-[[Category: Zhao, Y.]]
+[[Category: Zhao Y]]
-[[Category: ARS]]
-[[Category: MG]]
-[[Category: ZN]]
-[[Category: pde phosphodiesterase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:48:00 2007''

1f0j

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Current revision

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B

Structural highlights

Function

Evolutionary Conservation

See Also

References

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