7tz2
From Proteopedia
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| - | ==Structure of | + | ==Structure of the Fibrinogen C-terminal domain of FGL1== |
<StructureSection load='7tz2' size='340' side='right'caption='[[7tz2]], [[Resolution|resolution]] 2.55Å' scene=''> | <StructureSection load='7tz2' size='340' side='right'caption='[[7tz2]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZ2 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tz2 OCA], [https://pdbe.org/7tz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7tz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tz2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tz2 OCA], [https://pdbe.org/7tz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7tz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tz2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/FGL1_HUMAN FGL1_HUMAN]] Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).<ref>PMID:11470158</ref> <ref>PMID:19880967</ref> <ref>PMID:30580966</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Luca | + | [[Category: Luca VC]] |
| - | [[Category: Ming | + | [[Category: Ming Q]] |
| - | [[Category: Tran | + | [[Category: Tran TH]] |
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Current revision
Structure of the Fibrinogen C-terminal domain of FGL1
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