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3p1a

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Current revision (17:00, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3p1a' size='340' side='right'caption='[[3p1a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3p1a' size='340' side='right'caption='[[3p1a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P1A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P1A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYT1, PKMYT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1a OCA], [https://pdbe.org/3p1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p1a RCSB], [https://www.ebi.ac.uk/pdbsum/3p1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p1a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1a OCA], [https://pdbe.org/3p1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p1a RCSB], [https://www.ebi.ac.uk/pdbsum/3p1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p1a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref>PMID:9001210</ref> <ref>PMID:10373560</ref>
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[https://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref>PMID:9001210</ref> <ref>PMID:10373560</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Berridge G]]
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[[Category: Berridge, G]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Chaikuad A]]
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[[Category: Chaikuad, A]]
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[[Category: Cooper CDO]]
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[[Category: Cooper, C D.O]]
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[[Category: Edwards AM]]
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[[Category: Delft, F von]]
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[[Category: Eswaran J]]
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[[Category: Edwards, A M]]
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[[Category: Fedorov O]]
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[[Category: Eswaran, J]]
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[[Category: Knapp S]]
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[[Category: Fedorov, O]]
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[[Category: Kroeler T]]
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[[Category: Knapp, S]]
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[[Category: Krojer T]]
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[[Category: Kroeler, T]]
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[[Category: Muniz JRC]]
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[[Category: Krojer, T]]
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[[Category: Pike ACW]]
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[[Category: Muniz, J R.C]]
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[[Category: Vollmar M]]
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[[Category: Pike, A C.W]]
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[[Category: Weigelt J]]
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[[Category: Structural genomic]]
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[[Category: Von Delft F]]
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[[Category: Vollmar, M]]
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[[Category: Weigelt, J]]
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[[Category: Membrane-associated protein kinase]]
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[[Category: Protein kinase]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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[[Category: Tyrosine- and threonine-specific kinase]]
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Current revision

Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)

PDB ID 3p1a

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