3p45
From Proteopedia
(Difference between revisions)
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<StructureSection load='3p45' size='340' side='right'caption='[[3p45]], [[Resolution|resolution]] 2.53Å' scene=''> | <StructureSection load='3p45' size='340' side='right'caption='[[3p45]], [[Resolution|resolution]] 2.53Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3p45]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3p45]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P45 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p45 OCA], [https://pdbe.org/3p45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p45 RCSB], [https://www.ebi.ac.uk/pdbsum/3p45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p45 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p45 OCA], [https://pdbe.org/3p45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p45 RCSB], [https://www.ebi.ac.uk/pdbsum/3p45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p45 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dominguez | + | [[Category: Dominguez C]] |
| - | [[Category: Kiselyov | + | [[Category: Kiselyov A]] |
| - | [[Category: Lamers | + | [[Category: Lamers MBAC]] |
| - | [[Category: Maillard | + | [[Category: Maillard M]] |
| - | [[Category: Mueller | + | [[Category: Mueller I]] |
| - | [[Category: Munoz | + | [[Category: Munoz I]] |
| - | [[Category: Ritchie | + | [[Category: Ritchie AJ]] |
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Current revision
Crystal structure of apo-caspase-6 at physiological pH
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