7xtp
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7xtp is ON HOLD Authors: Brown, C.J., Frosi, Y., Jiang, S., Lin, Y.C. Description: eIF4E in Complex with a Disulphide-Free Autonomous VH Domain [[C...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==eIF4E in Complex with a Disulphide-Free Autonomous VH Domain== | |
| + | <StructureSection load='7xtp' size='340' side='right'caption='[[7xtp]], [[Resolution|resolution]] 1.83Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7xtp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XTP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.828Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGO:[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]+PHOSPHONO+HYDROGEN+PHOSPHATE'>MGO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xtp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xtp OCA], [https://pdbe.org/7xtp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xtp RCSB], [https://www.ebi.ac.uk/pdbsum/7xtp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xtp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Antibody 3D structures|Antibody 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Brown | + | __TOC__ |
| - | [[Category: Frosi | + | </StructureSection> |
| - | [[Category: Jiang | + | [[Category: Homo sapiens]] |
| - | [[Category: Lin | + | [[Category: Large Structures]] |
| + | [[Category: Brown CJ]] | ||
| + | [[Category: Frosi Y]] | ||
| + | [[Category: Jiang S]] | ||
| + | [[Category: Lin YC]] | ||
Current revision
eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
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Categories: Homo sapiens | Large Structures | Brown CJ | Frosi Y | Jiang S | Lin YC
