This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7t0x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:06, 1 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7t0x' size='340' side='right'caption='[[7t0x]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
<StructureSection load='7t0x' size='340' side='right'caption='[[7t0x]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7t0x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0X FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7t0x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0X FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0x OCA], [https://pdbe.org/7t0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0x RCSB], [https://www.ebi.ac.uk/pdbsum/7t0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0x ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0x OCA], [https://pdbe.org/7t0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0x RCSB], [https://www.ebi.ac.uk/pdbsum/7t0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0x ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/PSMA3_STAA8 PSMA3_STAA8] Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
-
SignificanceThe formation of cross-alpha amyloids has been shown by crystallographic analysis of the highly cytolytic peptide PSMalpha3, a secreted virulence factor associated with the human pathogen Staphylococcus aureus. However, the relationship of the crystallographic cross-alpha structure to self-assembled filaments of PSMalpha3 and its relevance to other phenol-soluble modulin (PSM) peptides remained an open question. We report the cryo-electron microscopy structural analysis of three nanotubes derived from self-assembly of PSMalpha3 and PSMbeta2 peptides in aqueous solution. In each case, the nanotubes are derived from self-association of cross-alpha amyloid protofilaments. The self-assembly behavior of S. aureus PSMalpha3 and PSMbeta2 peptides provides strong evidence for the importance of the cross-alpha fold in self-assembled peptide and protein structures in general and for PSMs in particular.
+
-
 
+
-
Phenol-soluble modulins PSMalpha3 and PSMbeta2 form nanotubes that are cross-alpha amyloids.,Kreutzberger MAB, Wang S, Beltran LC, Tuachi A, Zuo X, Egelman EH, Conticello VP Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2121586119. doi:, 10.1073/pnas.2121586119. Epub 2022 May 9. PMID:35533283<ref>PMID:35533283</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 7t0x" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Beltran, L C]]
+
[[Category: Staphylococcus aureus]]
-
[[Category: Conticello, V P]]
+
[[Category: Beltran LC]]
-
[[Category: Egelman, E H]]
+
[[Category: Conticello VP]]
-
[[Category: Kreutzberger, M A]]
+
[[Category: Egelman EH]]
-
[[Category: Wang, S]]
+
[[Category: Kreutzberger MA]]
-
[[Category: Amyloid]]
+
[[Category: Wang S]]
-
[[Category: Cross-alpha]]
+
-
[[Category: Nanotube]]
+
-
[[Category: Protein fibril]]
+

Current revision

Structure of the larger diameter PSMalpha3 nanotube

PDB ID 7t0x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7t0x"
Personal tools