3pry

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Current revision (10:00, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3pry' size='340' side='right'caption='[[3pry]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='3pry' size='340' side='right'caption='[[3pry]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AB1, HSP90B, HSPC2, HSPCB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pry OCA], [https://pdbe.org/3pry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pry RCSB], [https://www.ebi.ac.uk/pdbsum/3pry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pry ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pry OCA], [https://pdbe.org/3pry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pry RCSB], [https://www.ebi.ac.uk/pdbsum/3pry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pry ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref>
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[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Ayinampudi, V]]
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[[Category: Ayinampudi V]]
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[[Category: Berridge, G]]
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[[Category: Berridge G]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bullock, A]]
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[[Category: Bullock A]]
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[[Category: Chaikuad, A]]
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[[Category: Chaikuad A]]
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[[Category: Che, K H]]
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[[Category: Che KH]]
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[[Category: Cooper, C D.O]]
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[[Category: Cooper CDO]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: Keates T]]
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[[Category: Keates, T]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Muniz JRC]]
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[[Category: Muniz, J R.C]]
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[[Category: Phillips C]]
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[[Category: Phillips, C]]
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[[Category: Pilka E]]
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[[Category: Pilka, E]]
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[[Category: Sharpe TD]]
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[[Category: Structural genomic]]
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[[Category: Thangaratnarajah C]]
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[[Category: Sharpe, T D]]
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[[Category: Vollmar M]]
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[[Category: Thangaratnarajah, C]]
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[[Category: Weigelt J]]
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[[Category: Vollmar, M]]
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[[Category: Yue WW]]
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[[Category: Weigelt, J]]
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[[Category: Zimmermann T]]
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[[Category: Yue, W W]]
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[[Category: Von Delft F]]
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[[Category: Zimmermann, T]]
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[[Category: Chaperone]]
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[[Category: Heat shock protein]]
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[[Category: Hsp90b]]
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[[Category: Sgc]]
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Current revision

Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution

PDB ID 3pry

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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