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3q0v

From Proteopedia

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Current revision (10:45, 21 February 2024) (edit) (undo)
 
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<StructureSection load='3q0v' size='340' side='right'caption='[[3q0v]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3q0v' size='340' side='right'caption='[[3q0v]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LL4:4-METHYL-1-{4-[3-(THIOPHEN-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}PENTAN-1-ONE'>LL4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3o8g|3o8g]], [[3o8l|3o8l]], [[3g1m|3g1m]], [[3g1l|3g1l]], [[3g1o|3g1o]], [[1u9n|1u9n]], [[3q0u|3q0u]], [[3q0w|3q0w]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LL4:4-METHYL-1-{4-[3-(THIOPHEN-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}PENTAN-1-ONE'>LL4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ethR, etaR, MT3970, Rv3855 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0v OCA], [https://pdbe.org/3q0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0v RCSB], [https://www.ebi.ac.uk/pdbsum/3q0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0v OCA], [https://pdbe.org/3q0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0v RCSB], [https://www.ebi.ac.uk/pdbsum/3q0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baulard, A]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Brodin, P]]
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[[Category: Baulard A]]
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[[Category: Carette, X]]
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[[Category: Brodin P]]
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[[Category: Christophe, T]]
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[[Category: Carette X]]
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[[Category: Demirkaya, F]]
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[[Category: Christophe T]]
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[[Category: Deprez, B]]
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[[Category: Demirkaya F]]
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[[Category: Desroses, M]]
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[[Category: Deprez B]]
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[[Category: Dirie, B]]
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[[Category: Desroses M]]
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[[Category: Flipo, M]]
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[[Category: Dirie B]]
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[[Category: Jeon, H K]]
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[[Category: Flipo M]]
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[[Category: Lens, Z]]
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[[Category: Jeon HK]]
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[[Category: Leroux, F]]
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[[Category: Lens Z]]
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[[Category: Locht, C]]
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[[Category: Leroux F]]
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[[Category: Piveteau, C]]
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[[Category: Locht C]]
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[[Category: Rucktooa, P]]
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[[Category: Piveteau C]]
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[[Category: Villeret, V]]
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[[Category: Rucktooa P]]
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[[Category: Willand, N]]
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[[Category: Villeret V]]
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[[Category: Tetr family]]
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[[Category: Willand N]]
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[[Category: Transcription-transcription inhibitor complex]]
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[[Category: Transcriptional repressor]]
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Current revision

ETHR From mycobacterium tuberculosis in complex with compound bdm31369

PDB ID 3q0v

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