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Alcohol dehydrogenase 3D structures

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Current revision (07:25, 16 February 2023) (edit) (undo)
 
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Line 9: Line 9:
**[[3jv7]] – RrADH I – ''Rhodococcus rubber''<br />
**[[3jv7]] – RrADH I – ''Rhodococcus rubber''<br />
**[[4w6z]] – yADH I – yeast<br />
**[[4w6z]] – yADH I – yeast<br />
 +
**[[7kcq]] – yADH I – Cryo EM<br />
**[[4eex]] – LlADH I – ''Lactococcus lactis''<br />
**[[4eex]] – LlADH I – ''Lactococcus lactis''<br />
**[[4eez]] – LlADH I (mutant)
**[[4eez]] – LlADH I (mutant)
Line 18: Line 19:
**[[1u3w]] - hADH I γ chain + inhibitor<br />
**[[1u3w]] - hADH I γ chain + inhibitor<br />
**[[1ht0]] - hADH I γ chain (mutant) + NAD<br />
**[[1ht0]] - hADH I γ chain (mutant) + NAD<br />
 +
**[[7kc2]], [[7kjy]] – yADH I + NAD – Cryo EM<br />
**[[6c49]] – ADH I + Zn – ''Acinetobacter baumannii''<br />
**[[6c49]] – ADH I + Zn – ''Acinetobacter baumannii''<br />
 +
**[[6qhe]] – ADH + NAD – Arthrobacter<br />
*ADH I ternary complex
*ADH I ternary complex
Line 28: Line 31:
**[[1deh]], [[1hdy]] - hADH I β chain + NAD + pyrazole derivative<br />
**[[1deh]], [[1hdy]] - hADH I β chain + NAD + pyrazole derivative<br />
**[[1htb]] - hADH I β3 chain + NAD + pyrazole derivative<br />
**[[1htb]] - hADH I β3 chain + NAD + pyrazole derivative<br />
-
**[[2xaa]] – RrADH I + NAD + alcohol<br />
 
-
**[[6ffx]] – RrADH I + Zn + NAD<br />
 
-
**[[6ffz]], [[5o8h]], [[5o8q]], [[5o9d]], [[5o9f]], [[6fg0]], [[5od3]] – RrADH I (mutant) + Zn + NAD<br />
 
**[[3fx4]] – pADH I + NADP + inhibitor – pig<br />
**[[3fx4]] – pADH I + NADP + inhibitor – pig<br />
**[[4w6z]] – yADH I + Zn + NAD derivative<br />
**[[4w6z]] – yADH I + Zn + NAD derivative<br />
**[[5env]] – yADH I + Zn + NAD + alcohol<br />
**[[5env]] – yADH I + Zn + NAD + alcohol<br />
 +
**[[6ffx]] – RrADH I + Zn + NAD<br />
 +
**[[6ffz]], [[5o8h]], [[5o8q]], [[5o9d]], [[5o9f]], [[6fg0]], [[5od3]] – RrADH I (mutant) + Zn + NAD<br />
*ADH II
*ADH II
Line 42: Line 44:
**[[3cos]] - hADH II + NAD + Zn<br />
**[[3cos]] - hADH II + NAD + Zn<br />
-
**[[3ox4]] - ZmADH II iron-dependent + NAD<br />
 
**[[1e3e]] – mADH II + NADH – mouse<br />
**[[1e3e]] – mADH II + NADH – mouse<br />
**[[1e3l]] - mADH II (mutant) + NADH<br />
**[[1e3l]] - mADH II (mutant) + NADH<br />
**[[1e3i]] - mADH II + NADH + inhibitor<br />
**[[1e3i]] - mADH II + NADH + inhibitor<br />
**[[5yln]] – ADH II + Zn – ''Streptococcus pneumoniae''<br />
**[[5yln]] – ADH II + Zn – ''Streptococcus pneumoniae''<br />
 +
**[[3ox4]] - ZmADH II iron-dependent + NAD<br />
*ADH III
*ADH III
Line 71: Line 73:
**[[1d1s]], [[1agn]] – hADH IV σ chain + NAD<br />
**[[1d1s]], [[1agn]] – hADH IV σ chain + NAD<br />
**[[1d1t]] - hADH IV σ chain (mutant) + NAD<br />
**[[1d1t]] - hADH IV σ chain (mutant) + NAD<br />
-
**[[2jhf]], [[2jhg]], [[1het]], [[1heu]], [[1hf3]], [[1ee2]], [[2oxi]], [[2ohx]], [[6adh]] - hoADH IV e chain + NAD<br />
+
**[[2jhf]], [[2jhg]], [[1het]], [[1heu]], [[1hf3]], [[1ee2]], [[2oxi]], [[2ohx]], [[6adh]], [[7udd]] - hoADH IV e chain + NAD<br />
**[[6nbb]] - hoADH IV e chain + NAD – Cryo EM<br />
**[[6nbb]] - hoADH IV e chain + NAD – Cryo EM<br />
**[[1adb]], [[1adc]], [[1adf]], [[1adg]], [[7adh]], [[5vn1]] - hoADH IV e chain + NAD derivative<br />
**[[1adb]], [[1adc]], [[1adf]], [[1adg]], [[7adh]], [[5vn1]] - hoADH IV e chain + NAD derivative<br />
Line 79: Line 81:
**[[3oq6]], [[1qv6]], [[1qv7]], [[1a71]], [[1axe]], [[1axg]], [[4nfh]], [[4nfs]], [[4ng5]], [[5kje]], [[5kjc]], [[5kj6]], [[5kj1]], [[5kcz]], [[5kcp]], [[5cdt]], [[5cds]], [[5cdg]], [[6o91]], [[6oa7]], [[6owm]], [[6owp]] – hoADH IV e chain (mutant) + NAD + alcohol<br />
**[[3oq6]], [[1qv6]], [[1qv7]], [[1a71]], [[1axe]], [[1axg]], [[4nfh]], [[4nfs]], [[4ng5]], [[5kje]], [[5kjc]], [[5kj6]], [[5kj1]], [[5kcz]], [[5kcp]], [[5cdt]], [[5cds]], [[5cdg]], [[6o91]], [[6oa7]], [[6owm]], [[6owp]] – hoADH IV e chain (mutant) + NAD + alcohol<br />
-
**[[4dwv]], [[4dxh]], [[5kjf]], [[6xt2]], [[7jqa]], [[7k35]] - hoADH IV e chain + NAD + alcohol<br />
+
**[[4dwv]], [[4dxh]], [[5kjf]], [[6xt2]], [[7jqa]], [[7k35]], [[7ua6]], [[7uc9]], [[7uca]], [[7ucu]], [[7ude]], [[7udr]], [[7uec]], [[7uee]], [[7uef]], [[7uei]], [[7uej]], [[7uhv]], 7uhw]], [[7uhx]] - hoADH IV e chain + NAD + alcohol<br />
**[[1p1r]], [[1ldy]], [[1lde]] - hoADH IV e chain + NADH + formamide derivative<br />
**[[1p1r]], [[1ldy]], [[1lde]] - hoADH IV e chain + NADH + formamide derivative<br />
**[[1n92]] - hoADH IV e chain + NAD + pyrazole derivative<br />
**[[1n92]] - hoADH IV e chain + NAD + pyrazole derivative<br />
Line 109: Line 111:
**[[4bmn]] – ReADH - ''Ralstonia eutropha''<br />
**[[4bmn]] – ReADH - ''Ralstonia eutropha''<br />
**[[4z6k]] – ADH - ''Moraxella''<br />
**[[4z6k]] – ADH - ''Moraxella''<br />
 +
**[[7cyi]] – ADH – ''Artemisia annua''<br />
*ADH binary complex
*ADH binary complex
 +
**[[1agn]] – hADH (sigma) +NAD<br />
 +
**[[1cdo]] – ADH + NAD - cod<br />
**[[3l77]], [[3tn7]] – ADH short-chain + NADP – ''Thermococcus sibiricus''<br />
**[[3l77]], [[3tn7]] – ADH short-chain + NADP – ''Thermococcus sibiricus''<br />
**[[1h2b]] – ADH + NAD – ''Aeropyrum pernix''<br />
**[[1h2b]] – ADH + NAD – ''Aeropyrum pernix''<br />
Line 118: Line 123:
**[[3ip1]] – TmADH + Cd<br />
**[[3ip1]] – TmADH + Cd<br />
**[[1b16]], [[1b14]], [[1b15]] - SlADH + NAD derivative<br />
**[[1b16]], [[1b14]], [[1b15]] - SlADH + NAD derivative<br />
-
**[[1cdo]] – ADH + NAD - cod<br />
 
-
**[[1rhc]] – ADH F420-dependent +F420-acetone – ''Methanoculleus thermophilus''<br />
 
-
**[[1agn]] – hADH (sigma) +NAD<br />
 
**[[3pii]] – GsADH + butyramide<br />
**[[3pii]] – GsADH + butyramide<br />
**[[3rj5]], [[3rj9]] – SlADH (mutant) + NAD<br />
**[[3rj5]], [[3rj9]] – SlADH (mutant) + NAD<br />
Line 132: Line 134:
*ADH ternary complex
*ADH ternary complex
 +
**[[3cv7]] – pADH + NAD + NAP<br />
**[[1mg5]] – ADH + NADH + acetate – ''Drosophila melanogaster''<br />
**[[1mg5]] – ADH + NADH + acetate – ''Drosophila melanogaster''<br />
**[[1r37]] – SsADH + NAD + alcohol<br />
**[[1r37]] – SsADH + NAD + alcohol<br />
Line 137: Line 140:
**[[1b2l]] - SlADH + NAD + cyclohexanone<br />
**[[1b2l]] - SlADH + NAD + cyclohexanone<br />
**[[1llu]] - ADH + NAD + alcohol – ''Pseudomonas aeruginosa''<br />
**[[1llu]] - ADH + NAD + alcohol – ''Pseudomonas aeruginosa''<br />
-
**[[3cv7]] – pADH + NAD + NAP<br />
 
**[[3rf7]] – SoADH + NAD + Fe + Ni<br />
**[[3rf7]] – SoADH + NAD + Fe + Ni<br />
**[[3s2e]] – ReADH + NAD + Zn<br />
**[[3s2e]] – ReADH + NAD + Zn<br />
Line 155: Line 157:
**[[4gac]] - mADH<br />
**[[4gac]] - mADH<br />
-
**[[4hfj]] – toADH – tobacco<br />
+
**[[4hfj]] – toADH – tobacco<br />
-
**[[1ped]] - CbADH – ''Clostridium beijerinckii''<br />
+
-
**[[2b83]], [[1jqb]] – CbADH (mutant) <br />
+
**[[2nvb]] - TbADH (mutant) – ''Thermoanaerobacter brockii''<br />
**[[2nvb]] - TbADH (mutant) – ''Thermoanaerobacter brockii''<br />
**[[3ftn]], [[3fpc]], [[3fpl]], [[3fsr]] – ADH chimera<br />
**[[3ftn]], [[3fpc]], [[3fpl]], [[3fsr]] – ADH chimera<br />
Line 166: Line 166:
*NADP-dependent ADH complex
*NADP-dependent ADH complex
-
**[[1kev]] – CbADH + NADPH<br />
 
-
**[[1bxz]] – CbADH catalytic domain + alcohol<br />
 
**[[1ykf]] – TbADH + NADP<br />
**[[1ykf]] – TbADH + NADP<br />
**[[3h4g]] – pADH + NADP<br />
**[[3h4g]] – pADH + NADP<br />
Line 181: Line 179:
**[[5yvm]] – bspADH + Mn + NADP derivative – brine sea pool<br />
**[[5yvm]] – bspADH + Mn + NADP derivative – brine sea pool<br />
**[[5yvr]], [[5yvs]] – bspADH (mutant) + Mn + NADP <br />
**[[5yvr]], [[5yvs]] – bspADH (mutant) + Mn + NADP <br />
-
**[[5z2x]] – ADH + NADP – ''Kluyveromyces polyspora''<br />
+
**[[5z2x]], [[7c3v]] – ADH + NADP – ''Kluyveromyces polyspora''<br />
-
**[[7utc]] – TeADH + DMSO + NADP + Zn – ''Thermoanaerobacter ethanolicus''<br />
+
-
**[[7jns]], [[7uut]] – TeADH (mutant) + NADP + Zn <br />
+
*R-specific ADH
*R-specific ADH
Line 215: Line 211:
**[[4cvc]], [[4cvb]] – ADH + Zn + PQQ + propanoate – ''Pseudogluconobacter saccharoketogenes''<br />
**[[4cvc]], [[4cvb]] – ADH + Zn + PQQ + propanoate – ''Pseudogluconobacter saccharoketogenes''<br />
 +
 +
*Secondary ADH
 +
 +
**[[7uut]], [[7ux4]] – TpSADH (mutant) + NADP + alcohol<br />
 +
**[[6kq9]], [[6kqb]] - SADH – ''Micrococcus luteus''<br />
 +
**[[1rhc]] – SADH +F420-acetone –'' Methanoculleus thermophilus''<br />
 +
**[[7utc]] – TeSADH + DMSO + NADP + Zn – ''Thermoanaerobacter ethanolicus''<br />
 +
**[[7uut]] – TeSADH (mutant) + NADP + Zn <br />
 +
**[[1ped]] - CbSADH – ''Clostridium beijerinckii''<br />
 +
**[[2b83]], [[1jqb]] – CbSADH (mutant)<br />
 +
**[[1kev]] – CbSADH + NADPH<br />
 +
**[[1bxz]] – CbSADH catalytic domain + alcohol<br />
 +
**[[2xaa]] – RrSADH I + NAD + alcohol<br />
*Hydroxyacyl-CoA dehydrogenase (HADH)
*Hydroxyacyl-CoA dehydrogenase (HADH)
-
**Short chain HADH
+
**Short chain HADH (SCHAD)
-
***[[1so8]] – hSHCDH II – human<BR />
+
***[[1so8]] – hSCHAD II <BR />
-
***[[3rqs]] - hSHCDH <BR />
+
***[[3rqs]] - hSCHAD <BR />
-
***[[1f14]] - hSHCDH (mutant)
+
***[[1f14]] - hSCHAD (mutant)
**Short chain HADH binary complex
**Short chain HADH binary complex
-
***[[1f12]] - hSHCDH (mutant) + hydroxybutyryl-CoA<BR />
+
***[[1f12]] - hSCHAD (mutant) + hydroxybutyryl-CoA<BR />
-
***[[1f17]], [[1lsj]], [[1lso]] - hSHCDH (mutant) + NAD<BR />
+
***[[1f17]], [[1lsj]], [[1lso]] - hSCHAD (mutant) + NAD<BR />
-
***[[1zbq]] - hSHCDH IV + NAD<BR />
+
***[[1zbq]] - hSCHAD IV + NAD<BR />
-
***[[1e3s]] - rSHCDH + NAD – rat
+
***[[1e3s]] - rSCHAD + NAD – rat
**Short chain HADH ternary complex
**Short chain HADH ternary complex
-
***[[1u7t]] - hSHCDH II + inhibitor + NAD<BR />
+
***[[1u7t]] - hSCHAD II + inhibitor + NAD<BR />
-
***[[1f0y]] - hSHCDH + acetoacetyl-CoA + NAD<BR />
+
***[[1f0y]] - hSCHAD + acetoacetyl-CoA + NAD<BR />
-
***[[1il0]], [[1m75]], [[1m76]] - hSHCDH (mutant) + acetoacetyl-CoA + NAD<BR />
+
***[[1il0]], [[1m75]], [[1m76]] - hSCHAD (mutant) + acetoacetyl-CoA + NAD<BR />
-
***[[1e3w]] - rSHCDH + 3-keto-butyrate + NAD<BR />
+
***[[1e3w]] - rSCHAD + 3-keto-butyrate + NAD<BR />
-
***[[1e6w]] - rSHCDH + estradiol + NAD<BR />
+
***[[1e6w]] - rSCHAD + estradiol + NAD<BR />
*Unspecified HADH
*Unspecified HADH

Current revision

3D Structures of Alcohol dehydrogenase

Updated on 16-February-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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