Journal:MicroPubl Biol:000570
From Proteopedia
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*<scene name='91/913474/Cv/6'>1st view</scene>. | *<scene name='91/913474/Cv/6'>1st view</scene>. | ||
*<scene name='91/913474/Cv/9'>2nd view. Rotated ~ 90° clockwise around the vertical axis, respective to the orientation shown at 1st view</scene>. | *<scene name='91/913474/Cv/9'>2nd view. Rotated ~ 90° clockwise around the vertical axis, respective to the orientation shown at 1st view</scene>. | ||
| - | *<scene name='91/913474/Cv/8'>3rd view. | + | *<scene name='91/913474/Cv/8'>3rd view. Rotated ~ 90° clockwise around the horizontal axis, respective to the orientation shown at 1st view</scene>. |
The crystallographic model (PDB [[6pup]]), electrostatic potential: | The crystallographic model (PDB [[6pup]]), electrostatic potential: | ||
*<scene name='91/913474/Cv/10'>1st view</scene>. | *<scene name='91/913474/Cv/10'>1st view</scene>. | ||
*<scene name='91/913474/Cv/11'>2nd view. Rotated ~ 90° clockwise around the vertical axis, respective to the orientation shown at 1st view</scene>. | *<scene name='91/913474/Cv/11'>2nd view. Rotated ~ 90° clockwise around the vertical axis, respective to the orientation shown at 1st view</scene>. | ||
| - | *<scene name='91/913474/Cv/12'>3rd view | + | *<scene name='91/913474/Cv/12'>3rd view. Rotated ~ 90° clockwise around the horizontal axis, respective to the orientation shown at 1st view</scene>. |
The crystallographic model (PDB [[6pup]]) contains two Mn (II) ions bridged by a water molecule (salmon and red spheres, respectively). | The crystallographic model (PDB [[6pup]]) contains two Mn (II) ions bridged by a water molecule (salmon and red spheres, respectively). | ||
*<scene name='91/913474/Cv/14'>1st view</scene>. | *<scene name='91/913474/Cv/14'>1st view</scene>. | ||
| - | *<scene name='91/913474/Cv/15'>2nd view after ~180° rotation</scene>. | + | *<scene name='91/913474/Cv/15'>2nd view after ~180° rotation around the vertical axis</scene>. |
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| + | <span class="bg-yellow"><span class="far fa-hand-point-right"></span> Remember to drag the structures with the mouse to rotate them.</span> | ||
<scene name='91/913474/Cv/21'>FMN binding site</scene>. FMN is in yellow ball-and-stick representation. The residues contacting FMN, hydrogen bonds (white dashed lines), and selected water molecules (red spheres) are shown. The TYW1 residues are in pink. | <scene name='91/913474/Cv/21'>FMN binding site</scene>. FMN is in yellow ball-and-stick representation. The residues contacting FMN, hydrogen bonds (white dashed lines), and selected water molecules (red spheres) are shown. The TYW1 residues are in pink. | ||
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TYW1 structural similarity to enzymes which couple FAD/FMN and NADP(H) coenzymes for their activity, together with the presence of an unexpected metal binding site, point to a very complex regulation of TYW1 by cell energy metabolism. | TYW1 structural similarity to enzymes which couple FAD/FMN and NADP(H) coenzymes for their activity, together with the presence of an unexpected metal binding site, point to a very complex regulation of TYW1 by cell energy metabolism. | ||
| + | '''PDB references:''' 1.9 A crystal structure of flavodoxin-like domain of ''Schizosaccharomyces japonicus'' putative tRNAPhe 4-demethylwyosine synthase TYW1 in complex with FMN [[6pup]]; 1.56 A crystal structure of flavodoxin-like domain of ''Schizosaccharomyces japonicus'' putative tRNAPhe 4-demethylwyosine synthase TYW1 in complex with FMN [[6puq]]. | ||
<b>References</b><br> | <b>References</b><br> | ||
Current revision
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