7xzq

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(New page: '''Unreleased structure''' The entry 7xzq is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (18:04, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7xzq is ON HOLD
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==Crystal structure of TNIK-thiopeptide TP1 complex==
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<StructureSection load='7xzq' size='340' side='right'caption='[[7xzq]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xzq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XZQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xzq OCA], [https://pdbe.org/7xzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xzq RCSB], [https://www.ebi.ac.uk/pdbsum/7xzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xzq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TNIK_HUMAN TNIK_HUMAN] Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.<ref>PMID:10521462</ref> <ref>PMID:15342639</ref> <ref>PMID:19061864</ref> <ref>PMID:19816403</ref> <ref>PMID:20159449</ref> <ref>PMID:21690388</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Chang JS]]
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[[Category: Goto Y]]
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[[Category: Hamada K]]
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[[Category: Nishimura H]]
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[[Category: Ogata K]]
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[[Category: Onaka H]]
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[[Category: Sengoku T]]
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[[Category: Suga H]]
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[[Category: Vinogradov AA]]
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[[Category: Zhang Y]]

Current revision

Crystal structure of TNIK-thiopeptide TP1 complex

PDB ID 7xzq

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