8a10
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8a10 is ON HOLD Authors: Newman, J.A., Gavard, A., Aitkenhead, H., Imprachim, N., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Bountra, C., Gi...) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143== | |
| + | <StructureSection load='8a10' size='340' side='right'caption='[[8a10]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8a10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A10 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a10 OCA], [https://pdbe.org/8a10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a10 RCSB], [https://www.ebi.ac.uk/pdbsum/8a10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a10 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293] | ||
| - | + | ==See Also== | |
| - | + | *[[Brachyury|Brachyury]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Aitkenhead H]] |
| - | [[Category: Burgess-Brown | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Burgess-Brown NA]] |
| - | [[Category: | + | [[Category: Gavard A]] |
| - | [[Category: | + | [[Category: Gileadi O]] |
| - | [[Category: | + | [[Category: Imprachim N]] |
| - | [[Category: | + | [[Category: Newman JA]] |
| + | [[Category: Sherestha L]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
| |||||||||||
