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8a1f
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8a1f is ON HOLD Authors: Hay, I.M., Graham, S.C., Sharpe, H.J., Deane, J.E. Description: PTPRK MIFN1 domains Category: Unreleased Structures [[...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human PTPRK N-terminal domains MAM-Ig-FN1== | |
| - | + | <StructureSection load='8a1f' size='340' side='right'caption='[[8a1f]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8a1f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A1F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a1f OCA], [https://pdbe.org/8a1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a1f RCSB], [https://www.ebi.ac.uk/pdbsum/8a1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a1f ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Graham | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PTPRK_HUMAN PTPRK_HUMAN] Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.<ref>PMID:19836242</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Deane JE]] | ||
| + | [[Category: Graham SC]] | ||
| + | [[Category: Hay IM]] | ||
| + | [[Category: Sharpe HJ]] | ||
Current revision
Human PTPRK N-terminal domains MAM-Ig-FN1
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