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8cz8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8cz8 is ON HOLD Authors: Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshin...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics== | |
| + | <StructureSection load='8cz8' size='340' side='right'caption='[[8cz8]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8cz8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZ8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cz8 OCA], [https://pdbe.org/8cz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cz8 RCSB], [https://www.ebi.ac.uk/pdbsum/8cz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cz8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Bandaranayake AD]] |
| - | [[Category: | + | [[Category: Carter J]] |
| - | [[Category: | + | [[Category: Chan MK]] |
| - | [[Category: | + | [[Category: Clarke M]] |
| - | [[Category: | + | [[Category: Correnti CE]] |
| - | [[Category: | + | [[Category: Friend DJ]] |
| - | [[Category: | + | [[Category: Lin I]] |
| - | [[Category: | + | [[Category: Mehlin C]] |
| - | [[Category: | + | [[Category: Meshinchi S]] |
| - | [[Category: | + | [[Category: Olson JM]] |
| + | [[Category: Pilat K]] | ||
| + | [[Category: Ruff RO]] | ||
| + | [[Category: Rupert PB]] | ||
| + | [[Category: Strong RK]] | ||
Current revision
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
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Categories: Homo sapiens | Large Structures | Bandaranayake AD | Carter J | Chan MK | Clarke M | Correnti CE | Friend DJ | Lin I | Mehlin C | Meshinchi S | Olson JM | Pilat K | Ruff RO | Rupert PB | Strong RK
