8d1k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==hBest1 Ca2+-bound partially open neck state== |
| + | <StructureSection load='8d1k' size='340' side='right'caption='[[8d1k]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8d1k]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.28Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1k OCA], [https://pdbe.org/8d1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1k RCSB], [https://www.ebi.ac.uk/pdbsum/8d1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BEST1_HUMAN BEST1_HUMAN] Nanophthalmos;Adult-onset foveomacular vitelliform dystrophy;Best vitelliform macular dystrophy;MRCS syndrome;Autosomal recessive bestrophinopathy;Autosomal dominant vitreoretinochoroidopathy;Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BEST1_HUMAN BEST1_HUMAN] Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.<ref>PMID:11904445</ref> <ref>PMID:12907679</ref> <ref>PMID:18400985</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Bestrophin 3D structures|Bestrophin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hendrickson WA]] | ||
| + | [[Category: Kittredge A]] | ||
| + | [[Category: Owji AP]] | ||
| + | [[Category: Tingting Y]] | ||
Current revision
hBest1 Ca2+-bound partially open neck state
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