7n5w
From Proteopedia
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| - | ==== | + | ==ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 23)== |
| - | <StructureSection load='7n5w' size='340' side='right'caption='[[7n5w]]' scene=''> | + | <StructureSection load='7n5w' size='340' side='right'caption='[[7n5w]], [[Resolution|resolution]] 2.24Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7n5w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N5W FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n5w OCA], [https://pdbe.org/7n5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n5w RCSB], [https://www.ebi.ac.uk/pdbsum/7n5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n5w ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n5w OCA], [https://pdbe.org/7n5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n5w RCSB], [https://www.ebi.ac.uk/pdbsum/7n5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n5w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Cheng X]] |
| + | [[Category: Horton JR]] | ||
| + | [[Category: Ren R]] | ||
Current revision
ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 23)
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