7ew5

==immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5==

<StructureSection load='7ew5' size='340' side='right'caption='[[7ew5]], [[Resolution|resolution]] 3.61&Aring;' scene=''>

<table><tr><td colspan='2'>[[7ew5]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_6 Human papillomavirus type 6] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EW5 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.606&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ew5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ew5 OCA], [https://pdbe.org/7ew5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ew5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ew5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ew5 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/Q9W9C6_9PAPI Q9W9C6_9PAPI] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002][RuleBase:RU361248]

==See Also==

*[[Antibody 3D structures|Antibody 3D structures]]

[[Category: Human papillomavirus type 6]]

[[Category: Mus musculus]]

[[Category: Wang ZP]]