Twinfilin
From Proteopedia
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<StructureSection load='3daw' size='400' side='right' caption='Structure of twinfilin-1 C-terminal ADF-H domain (green) complex with actin (cyan), ATP and Ca+2 ion (green (PDB code [[3daw]])' scene='80/805029/Cv/1'> | <StructureSection load='3daw' size='400' side='right' caption='Structure of twinfilin-1 C-terminal ADF-H domain (green) complex with actin (cyan), ATP and Ca+2 ion (green (PDB code [[3daw]])' scene='80/805029/Cv/1'> | ||
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== Function == | == Function == | ||
'''Twinfilin''' (Twi) is an actin-monomer-binding protein which is composed of 2 Actin Depolimerizing Factor Homology (ADF-H) domains. Twi forms a 1:1 complex with ADP-actin-monomer, inhibits nucleotide exchange on actin monomers and prevents assembly of the monomer to filaments<ref>PMID:11870207</ref>. | '''Twinfilin''' (Twi) is an actin-monomer-binding protein which is composed of 2 Actin Depolimerizing Factor Homology (ADF-H) domains. Twi forms a 1:1 complex with ADP-actin-monomer, inhibits nucleotide exchange on actin monomers and prevents assembly of the monomer to filaments<ref>PMID:11870207</ref>. | ||
| + | *'''Twinfilin 1''' is an actin-depolymerisation factor regulating actin filament assembly <ref>PMID:35168059</ref>. | ||
| + | *'''Twinfilin 2''' regulates stereocilia elongation for maintaining the architecture of cochlear hair bundles<ref>PMID:19955359</ref>. | ||
== Relevance == | == Relevance == | ||
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The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/6'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/7'>hydrogen bonds</scene> (twinfilin residues participating in interactions are colored in magenta) and <scene name='80/805029/Cv/8'>hydrophobic contacts</scene> (actin residues participating in interactions are colored according to hydrophobic/polar)<ref>PMID:18625842</ref>. | The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/6'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/7'>hydrogen bonds</scene> (twinfilin residues participating in interactions are colored in magenta) and <scene name='80/805029/Cv/8'>hydrophobic contacts</scene> (actin residues participating in interactions are colored according to hydrophobic/polar)<ref>PMID:18625842</ref>. | ||
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| - | </StructureSection> | ||
==3D structures of twinfilin== | ==3D structures of twinfilin== | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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