7y28

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "7y28" [edit=sysop:move=sysop])
Current revision (05:37, 5 July 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7y28 is ON HOLD
+
==Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1==
-
 
+
<StructureSection load='7y28' size='340' side='right'caption='[[7y28]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
-
Authors: Kim, S., Yoon, I., Son, J., Park, S., Hwang, K.Y.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[7y28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y28 FirstGlance]. <br>
-
Description: Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=F96:1-[6-(3-fluorophenyl)benzimidazol-1-yl]-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one'>F96</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Kim, S]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y28 OCA], [https://pdbe.org/7y28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y28 RCSB], [https://www.ebi.ac.uk/pdbsum/7y28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y28 ProSAT]</span></td></tr>
-
[[Category: Hwang, K.Y]]
+
</table>
-
[[Category: Son, J]]
+
== Function ==
-
[[Category: Park, S]]
+
[https://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref>
-
[[Category: Yoon, I]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Hwang KY]]
 +
[[Category: Kim S]]
 +
[[Category: Park S]]
 +
[[Category: Son J]]
 +
[[Category: Yoon I]]

Current revision

Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1

PDB ID 7y28

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7y28"
Personal tools