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8a28
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the astacin zymogen of LAST-MAM from Limulus polyphemus== | |
| - | + | <StructureSection load='8a28' size='340' side='right'caption='[[8a28]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8a28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A28 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a28 OCA], [https://pdbe.org/8a28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a28 RCSB], [https://www.ebi.ac.uk/pdbsum/8a28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a28 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B4F320_LIMPO B4F320_LIMPO] Zinc metalloprotease. Provoques deadhesion of endothelial cells from cell cultures, and also degradation of fibronectin, fibrinogen and gelatin in vitro. Its role in the venom is not fully understood but it might act as a spreading factor that facilitates diffusion of other venom toxins. Alternatively, it might be involved in the proteolytic processing of other venom toxins or it might play a role in extra-oral digestion of prey.[ARBA:ARBA00025529] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Limulus polyphemus]] | ||
| + | [[Category: Guevara T]] | ||
| + | [[Category: Rodriguez Banqueri A]] | ||
Current revision
Structure of the astacin zymogen of LAST-MAM from Limulus polyphemus
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