8d8i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Reverb alpha in complex with synthetic agonist== | |
| - | + | <StructureSection load='8d8i' size='340' side='right'caption='[[8d8i]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8d8i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D8I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QFX:(4S)-6-[([1,1-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine'>QFX</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d8i OCA], [https://pdbe.org/8d8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d8i RCSB], [https://www.ebi.ac.uk/pdbsum/8d8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d8i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NR1D1_HUMAN NR1D1_HUMAN] Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine.<ref>PMID:2539258</ref> <ref>PMID:1971514</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Burris PT]] | ||
| + | [[Category: Ciesielski F]] | ||
| + | [[Category: Hegazy L]] | ||
| + | [[Category: Ronin C]] | ||
Current revision
Crystal structure of Reverb alpha in complex with synthetic agonist
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