7qij
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Complex of the Yersinia enterocolitica Type III secretion export gate YscV with substrate:chaperone complex YscX:YscY== |
| - | <StructureSection load='7qij' size='340' side='right'caption='[[7qij]]' scene=''> | + | <StructureSection load='7qij' size='340' side='right'caption='[[7qij]], [[Resolution|resolution]] 4.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qij]] is a 54 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QIJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qij OCA], [https://pdbe.org/7qij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qij RCSB], [https://www.ebi.ac.uk/pdbsum/7qij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qij ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qij OCA], [https://pdbe.org/7qij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qij RCSB], [https://www.ebi.ac.uk/pdbsum/7qij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qij ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LCRD_YEREN LCRD_YEREN] Could be involved in the secretion of the yop virulence proteins. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Several gram-negative bacteria employ type III secretion systems (T3SS) to inject effector proteins into eukaryotic host cells directly from the bacterial cytoplasm. The export gate SctV (YscV in Yersinia) binds substrate:chaperone complexes such as YscX:YscY, which are essential for formation of a functional T3SS. Here, we present structures of the YscX:YscY complex alone and bound to nonameric YscV. YscX binds its chaperone YscY at two distinct sites, resembling the heterotrimeric complex of the T3SS needle subunit with its chaperone and co-chaperone. In the ternary complex the YscX N-terminus, which mediates YscX secretion, occupies a binding site within one YscV that is also used by flagellar chaperones, suggesting the interaction's importance for substrate recognition. The YscX C-terminus inserts between protomers of the YscV ring where the stalk protein binds to couple YscV to the T3SS ATPase. This primary YscV-YscX interaction is essential for the formation of a secretion-competent T3SS. | ||
| + | |||
| + | Direct interaction of a chaperone-bound type III secretion substrate with the export gate.,Gilzer D, Schreiner M, Niemann HH Nat Commun. 2022 Jun 2;13(1):2858. doi: 10.1038/s41467-022-30487-1. PMID:35654781<ref>PMID:35654781</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7qij" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Yersinia enterocolitica]] |
| + | [[Category: Gilzer D]] | ||
| + | [[Category: Niemann HH]] | ||
Current revision
Complex of the Yersinia enterocolitica Type III secretion export gate YscV with substrate:chaperone complex YscX:YscY
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