7w3u
From Proteopedia
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| - | ==== | + | ==USP34 catalytic domain in complex with UbPA== |
| - | <StructureSection load='7w3u' size='340' side='right'caption='[[7w3u]]' scene=''> | + | <StructureSection load='7w3u' size='340' side='right'caption='[[7w3u]], [[Resolution|resolution]] 3.13Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7w3u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3U FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3u OCA], [https://pdbe.org/7w3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3u RCSB], [https://www.ebi.ac.uk/pdbsum/7w3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3u ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYE:PROP-2-EN-1-AMINE'>AYE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3u OCA], [https://pdbe.org/7w3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3u RCSB], [https://www.ebi.ac.uk/pdbsum/7w3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UBP34_HUMAN UBP34_HUMAN] Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.<ref>PMID:21383061</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Thioesterase 3D structures|Thioesterase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Ming ZH]] |
| + | [[Category: Xu GL]] | ||
Current revision
USP34 catalytic domain in complex with UbPA
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