This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Undecaprenyl pyrophosphate synthase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:40, 11 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 2: Line 2:
== Function ==
== Function ==
-
'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.
+
'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPPS) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. UPPS or '''NUS1''' is a subunit of ''cis''-prenyltransferase<ref>PMID:27402831</ref>. Bisphosphonate drugs are UPP inhibitors.
== Relevance ==
== Relevance ==
-
UPP inhibitors are investigated as potential antibacterials<ref>PMID:26718796</ref>.
+
UPPS inhibitors are investigated as potential antibacterials<ref>PMID:26718796</ref>.
== Structural highlights ==
== Structural highlights ==
-
The <scene name='59/591995/Cv/5'>active site</scene> of UPP (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
+
The <scene name='59/591995/Cv/5'>active site</scene> of UPPS (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
-
</StructureSection>
+
==3D structures of undecaprenyl pyrophosphate synthase==
==3D structures of undecaprenyl pyrophosphate synthase==
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
[[Undecaprenyl pyrophosphate synthase 3D structures]]
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*Undecaprenyl pyrophosphate synthase
+
-
 
+
-
**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
+
-
**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPP – ''Escherichia coli''<br />
+
-
**[[1jp3]] – EcUPP (mutant) <br />
+
-
**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
+
-
**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
+
-
**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />
+
-
**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br />
+
-
**[[5xk3]] – StUPP – ''Streptmyces''<br />
+
-
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
+
-
**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />
+
-
**[[7jli]] – BsUPP – ''Bacillus subtilis''<br />
+
-
 
+
-
*Undecaprenyl pyrophosphate synthase complexes
+
-
 
+
-
**[[1ueh]] – EcUPP + Mg + SO4 + triton<br />
+
-
**[[1v7u]] – EcUPP + FPP <br />
+
-
**[[4u82]] – EcUPP + Mg + FPP derivative<br />
+
-
**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br />
+
-
**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br />
+
-
**[[1x07]] – EcUPP + Mg + PO4 + IPP<br />
+
-
**[[1x09]] – EcUPP (mutant) + Mg + IPP<br />
+
-
**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />
+
-
**[[5cqj]], [[5zhe]] – EcUPP + inhibitor <br />
+
-
**[[5kh4]] – SpUPP + FPP <br />
+
-
**[[5kh5]] – SpUPP + inhibitor <br />
+
-
**[[2dtn]] – HpUPP + pyrophosphate<br />
+
-
**[[3ugs]] - UPP + FPP analog – ''Campylobacter jejuni''<br />
+
-
**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br />
+
-
**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br />
+
-
**[[5xk8]] – StUPP + GPP <br />
+
-
**[[5xk6]] – StUPP + IPP <br />
+
-
**[[5xk7]] – StUPP + DMAPP <br />
+
-
**[[5xk9]] – StUPP + GSPP + DMAPP <br />
+
-
**[[6szg]], [[6szh]] - AbUPP + inhibitor<br />
+
-
**[[7jljj]], [[7jlm]], [[7jlr]] – BsUPP + inhibitor <br />
+
-
}}
+
== References ==
== References ==
<references/>
<references/>
-
 
+
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07).

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Undecaprenyl_pyrophosphate_synthase"
Personal tools