7ewh

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'''Unreleased structure'''
 
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The entry 7ewh is ON HOLD until 2023-11-25
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==Crystal structure of human PHGDH in complex with Homoharringtonine==
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<StructureSection load='7ewh' size='340' side='right'caption='[[7ewh]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7ewh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EWH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HMT:(3BETA)-O~3~-[(2R)-2,6-DIHYDROXY-2-(2-METHOXY-2-OXOETHYL)-6-METHYLHEPTANOYL]CEPHALOTAXINE'>HMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ewh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ewh OCA], [https://pdbe.org/7ewh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ewh RCSB], [https://www.ebi.ac.uk/pdbsum/7ewh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ewh ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
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== Function ==
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[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]
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Authors:
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==See Also==
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*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]]
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Description:
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cheng YS]]
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[[Category: Hsieh CH]]
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[[Category: Huang HC]]
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[[Category: Juan HF]]
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[[Category: Lee YS]]

Current revision

Crystal structure of human PHGDH in complex with Homoharringtonine

PDB ID 7ewh

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