7p4k

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'''Unreleased structure'''
 
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The entry 7p4k is ON HOLD until Paper Publication
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==Soluble epoxide hydrolase in complex with FL217==
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<StructureSection load='7p4k' size='340' side='right'caption='[[7p4k]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7p4k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P4K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IV:~{N}-[[4-(cyclopropylsulfonylamino)-2-(trifluoromethyl)phenyl]methyl]-1-[(3-fluorophenyl)methyl]indole-5-carboxamide'>5IV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p4k OCA], [https://pdbe.org/7p4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p4k RCSB], [https://www.ebi.ac.uk/pdbsum/7p4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p4k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
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Authors: Ni, X., Kramer, J.S., Lillich, F., Proschak, E., Chaikuad, A., Knapp, S., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
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Description: Soluble epoxide hydrolase in complex with FL217
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Chaikuad, A]]
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__TOC__
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[[Category: Proschak, E]]
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</StructureSection>
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[[Category: Lillich, F]]
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[[Category: Homo sapiens]]
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[[Category: Ni, X]]
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[[Category: Large Structures]]
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[[Category: Knapp, S]]
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[[Category: Chaikuad A]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Knapp S]]
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[[Category: Kramer, J.S]]
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[[Category: Kramer JS]]
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[[Category: Lillich F]]
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[[Category: Ni X]]
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[[Category: Proschak E]]

Current revision

Soluble epoxide hydrolase in complex with FL217

PDB ID 7p4k

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