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7xk8

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'''Unreleased structure'''
 
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The entry 7xk8 is ON HOLD until 2023-10-19
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==Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25==
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<StructureSection load='7xk8' size='340' side='right'caption='[[7xk8]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xk8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XK8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xk8 OCA], [https://pdbe.org/7xk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xk8 RCSB], [https://www.ebi.ac.uk/pdbsum/7xk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xk8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NMU_HUMAN NMU_HUMAN] Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.[UniProtKB:P12760] Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.[UniProtKB:P12760] Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.[UniProtKB:P12760]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Albert B]]
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[[Category: Cuiying Y]]
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[[Category: Gisela S]]
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[[Category: Han S]]
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[[Category: Holger W]]
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[[Category: Minmin L]]
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[[Category: Mu W]]
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[[Category: Shutian C]]
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[[Category: Tingting T]]
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[[Category: Wenru Z]]
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[[Category: Wu B]]
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[[Category: Xiaojing C]]
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[[Category: Zhao Q]]
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[[Category: Zhao W]]

Current revision

Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25

PDB ID 7xk8

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