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1fe0

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CRYSTAL STRUCTURE OF CADMIUM-HAH1

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Retrieved from "http://52.214.119.220/wiki/index.php/1fe0"

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-[[Image:1fe0.gif|left|200px]]<br />
-<applet load="1fe0" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1fe0, resolution 1.75&Aring;" />
-'''CRYSTAL STRUCTURE OF CADMIUM-HAH1'''<br />
-==Overview==
+==CRYSTAL STRUCTURE OF CADMIUM-HAH1==
-The Hah1 metallochaperone protein is implicated in copper delivery to the, Menkes and Wilson disease proteins. Hah1 and the N-termini of its target, proteins belong to a family of metal binding domains characterized by a, conserved MT/HCXXC sequence motif. The crystal structure of Hah1 has been, determined in the presence of Cu(I), Hg(II), and Cd(II). The 1.8 A, resolution structure of CuHah1 reveals a copper ion coordinated by Cys, residues from two adjacent Hah1 molecules. The CuHah1 crystal structure is, the first of a copper chaperone bound to copper and provides structural, support for direct metal ion exchange between conserved MT/HCXXC motifs in, two domains. The structures of HgHah1 and CdHah1, determined to 1.75 A, resolution, also reveal metal ion coordination by two MT/HCXXC motifs. An, extended hydrogen bonding network, unique to the complex of two Hah1, molecules, stabilizes the metal binding sites and suggests specific roles, for several conserved residues. Taken together, the structures provide, models for intermediates in metal ion transfer and suggest a detailed, molecular mechanism for protein recognition and metal ion exchange between, MT/HCXXC containing domains.
+<StructureSection load='1fe0' size='340' side='right'caption='[[1fe0]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1fe0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FE0 FirstGlance]. <br>
-FE0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SUC, SO4 and CD as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FE0 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fe0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fe0 OCA], [https://pdbe.org/1fe0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fe0 RCSB], [https://www.ebi.ac.uk/pdbsum/1fe0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fe0 ProSAT]</span></td></tr>
-Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins., Wernimont AK, Huffman DL, Lamb AL, O'Halloran TV, Rosenzweig AC, Nat Struct Biol. 2000 Sep;7(9):766-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10966647 10966647]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/1fe0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fe0 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Halloran, T.V.O.]]
+[[Category: Huffman DL]]
-[[Category: Huffman, D.L.]]
+[[Category: Lamb AL]]
-[[Category: Lamb, A.L.]]
+[[Category: O'Halloran TV]]
-[[Category: Rosenzweig, A.C.]]
+[[Category: Rosenzweig AC]]
-[[Category: Wernimont, A.K.]]
+[[Category: Wernimont AK]]
-[[Category: CD]]
-[[Category: SO4]]
-[[Category: SUC]]
-[[Category: beta-alpha-beta-beta-alpha-beta]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:52:14 2007''

1fe0

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CRYSTAL STRUCTURE OF CADMIUM-HAH1

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