7zvx
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution== | |
| - | + | <StructureSection load='7zvx' size='340' side='right'caption='[[7zvx]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zvx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZVX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AS:2-DEOXY-ADENOSINE+-5-THIO-MONOPHOSPHATE'>AS</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GS:GUANOSINE-5-THIO-MONOPHOSPHATE'>GS</scene>, <scene name='pdbligand=K2F:2-methoxyethyl-adenosine-5-thiophosphate'>K2F</scene>, <scene name='pdbligand=K39:2-methoxyethyl-guanosine-5-thiophosphate'>K39</scene>, <scene name='pdbligand=N7X:5-O-[(R)-hydroxy(sulfanylidene)-lambda~5~-phosphanyl]-2-O-(2-methoxyethyl)-5-methylcytidine'>N7X</scene>, <scene name='pdbligand=OKN:5-methyl-2-deoxycytidine-5-phosphorothioate'>OKN</scene>, <scene name='pdbligand=PST:THYMIDINE-5-THIOPHOSPHATE'>PST</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zvx OCA], [https://pdbe.org/7zvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zvx RCSB], [https://www.ebi.ac.uk/pdbsum/7zvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zvx ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ANXA2_HUMAN ANXA2_HUMAN] Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. |
| - | [[Category: Anderson | + | __TOC__ |
| - | [[Category: Mykhaylyk | + | </StructureSection> |
| - | [[Category: Nowotny | + | [[Category: Homo sapiens]] |
| - | [[Category: Skowronek | + | [[Category: Large Structures]] |
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Anderson B]] | ||
| + | [[Category: Hyjek-Skladanowska M]] | ||
| + | [[Category: Mykhaylyk V]] | ||
| + | [[Category: Nowotny M]] | ||
| + | [[Category: Orr C]] | ||
| + | [[Category: Seth P]] | ||
| + | [[Category: Skowronek K]] | ||
| + | [[Category: Wagner A]] | ||
Current revision
Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution
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