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8a62

From Proteopedia

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m (Protected "8a62" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8a62 is ON HOLD
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==Small molecule stabilizer (compound 2) for FOXO1 and 14-3-3==
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<StructureSection load='8a62' size='340' side='right'caption='[[8a62]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8a62]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A62 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=L7L:(3~{S})-1-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]carbonyl-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-3-carboxamide'>L7L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a62 OCA], [https://pdbe.org/8a62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a62 RCSB], [https://www.ebi.ac.uk/pdbsum/8a62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a62 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arkin MR]]
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[[Category: Brunsveld L]]
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[[Category: Centorrino F]]
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[[Category: Kenanova DN]]
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[[Category: Neitz J]]
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[[Category: Ottmann C]]
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[[Category: Sijbesma E]]
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[[Category: Vickery H]]
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[[Category: Virta J]]
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[[Category: Visser EJ]]
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[[Category: Zhong M]]

Current revision

Small molecule stabilizer (compound 2) for FOXO1 and 14-3-3

PDB ID 8a62

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OCA

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