Vesicle-associated membrane protein

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* '''VAMP4''' is involved in the pathway that functions to remove an inhibitor (probably synaptotagmin) of calcium-triggered exocytosis during the maturation of secretory granules.<br />
* '''VAMP4''' is involved in the pathway that functions to remove an inhibitor (probably synaptotagmin) of calcium-triggered exocytosis during the maturation of secretory granules.<br />
* '''VAMP8''' is involved in the homotypic fusion of secretary granules<ref>PMID:21733851</ref>.<br />
* '''VAMP8''' is involved in the homotypic fusion of secretary granules<ref>PMID:21733851</ref>.<br />
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'''Vesicle-associated membrane protein-associated protein''' (VAP) are endoplasmic reticulum proteins functioning in vesicle traffic, neurotransmitter release, microtubule organisation, lipid transport and unfolded protein transport<ref>PMID:18468439</ref>.
== Relevance ==
== Relevance ==
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There is a remarkable shape complementarity between the proteins involved in the SNARE-complexin-synaptotagmin interface<ref>PMID:28813412</ref>.
There is a remarkable shape complementarity between the proteins involved in the SNARE-complexin-synaptotagmin interface<ref>PMID:28813412</ref>.
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</StructureSection>
 
==3D structures of vesicle-associated membrane protein==
==3D structures of vesicle-associated membrane protein==
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[[Vesicle-associated membrane protein 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*VAMP A
 
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**[[2rr3]] – hVAMPA MSP domain + ORP-1 FFAT motif – human - NMR<br />
 
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**[[6tqr]] – hVAMPA MSP domain + STARD3 FFAT motif <br />
 
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**[[1z9l]] – rVAMPA MSP domain – rat<br />
 
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**[[1z9o]] – rVAMPA MSP domain + ORP-1 FFAT motif<br />
 
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**[[2cri]] – VAMPA MSP domain – mouse - NMR<br />
 
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*VAMP B/C
 
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**[[3ikk]] – hVAMPB/C MSP domain<br />
 
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**[[2mdk]] – hVAMPB/C MSP domain (mutant) - NMR<br />
 
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*VAMP2 or synaptobrevin-2
 
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**[[2kog]] – rVAMP2 - NMR<br />
 
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**[[1n7s]], [[1sfc]], [[3rk2]], [[3rl0]], [[6wvw]] – rVAMP2 + rStx1a SNARE motif + SNAP25 <br />
 
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**[[3hd7]], [[3ipd]] – rVAMP2 C-terminal + rStx1a SNARE motif + SNAP25 <br />
 
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**[[3rk3]] – rVAMP2 + rStx1a SNARE motif + SNAP25 + complexin-1 <br />
 
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**[[6ip1]] – rVAMP2 + rStx1a + SNAP25 + NAPA - Cryo EM <br />
 
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**[[5ccg]], [[5cch]], [[5cci]] – rVAMP2 + rStx1a SNARE motif + SNAP25 + synaptotagmin <br />
 
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**[[2n1t]] – rVAMP2 + rStx1a SNARE motif + SNAP25 + synaptotagmin - NMR<br />
 
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**[[5w5c]], [[5w5d]] – rVAMP2 + rStx1a SNARE motif + SNAP25 + synaptotagmin + complexin-1<br />
 
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**[[3j96]], [[3j97]], [[3j98]], [[3j99]], [[6mdm]], [[6mdn]] – rVAMP2 + rStx17 SNARE motif + SNAP25 + vesicle fusion ATPase + SNAP–alpha – Cryo EM<br />
 
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**[[6mti]] – rVAMP2 + synaptotagmin 1 + SNAP25 + syntaxin 1A – Cryo EM<br />
 
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*VAMP3 or synaptobrevin-3 or cellubrevin
 
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**[[5kj7]], [[5kj8]] – rVAMP3 + rStx1a SNARE motif + SNAP25 + synaptotagmin <br />
 
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*VAMP4
 
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**[[2nps]] – rVAMP4 SNARE motif + rStx13 SNARE motif + VAMP2 + hStx6 SNARE motif + VTI1-RP2 <br />
 
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*VAMP7
 
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**[[4b93]] – mVAMP7 + Ankyrin repeat domain-containing protein<br />
 
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*VAMP8 or endoprevin
 
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**[[7bv6]] – hVAMP8 + Stx17 SNARE motif + SNAP29 <br />
 
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**[[4wy4]], [[7bv6]] – rVAMP8 + rStx17 SNARE motif + SNAP25 <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Rat vesicle-associated membrane protein 2 SNARE motif (grey) complex with syntaxin-1A SNARE motif (green), SNAP25 SNARE motif (pink and yellow), complexin-1 (magenta), synaptotagmin-1 (cyan), glycerol and Mg+2 ion (green) (PDB code 5w5c)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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