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3rrd

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Current revision (09:44, 1 March 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3rrd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_virgata Dioclea virgata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RRD FirstGlance]. <br>
<table><tr><td colspan='2'>[[3rrd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_virgata Dioclea virgata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RRD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrd OCA], [https://pdbe.org/3rrd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rrd RCSB], [https://www.ebi.ac.uk/pdbsum/3rrd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rrd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrd OCA], [https://pdbe.org/3rrd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rrd RCSB], [https://www.ebi.ac.uk/pdbsum/3rrd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rrd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LECA_DIOVI LECA_DIOVI]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.[REFERENCE:1]<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
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[https://www.uniprot.org/uniprot/LECA_DIOVI LECA_DIOVI] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.[REFERENCE:1]<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The lectin of Dioclea virgata (DvirL), both native and complexed with X-man, was submitted to X-ray diffraction analysis and the crystal structure was compared to that of other Diocleinae lectins in order to better understand differences in biological properties, especially with regard to the ability of lectins to induce nitric oxide (NO) production. An association was observed between the volume of the carbohydrate recognition domain (CRD), the ability to induce NO production and the relative positions of Tyr12, Arg228 and Leu99. Thus, differences in biological activity induced by Diocleinae lectins are related to the configuration of amino acid residues in the carbohydrate binding site and to the structural conformation of subsequent regions capable of influencing site-ligand interactions. In conclusion, the ability of Diocleinae lectins to induce NO production depends on CRD configuration.
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Structure of Dioclea virgata lectin: Relations between carbohydrate binding site and nitric oxide production.,Batista da Nobrega R, Rocha BA, Gadelha CA, Santi-Gadelha T, Pires AF, Assreuy AM, Nascimento KS, Nagano CS, Sampaio AH, Cavada BS, Delatorre P Biochimie. 2011 Dec 16. PMID:22198239<ref>PMID:22198239</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rrd" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
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[[Category: Dioclea virgata]]
[[Category: Dioclea virgata]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Alencar, K L]]
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[[Category: Alencar KL]]
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[[Category: Bezerra, E H.S]]
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[[Category: Bezerra EHS]]
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[[Category: Bezerra, M J]]
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[[Category: Bezerra MJ]]
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[[Category: Cavada, B S]]
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[[Category: Cavada BS]]
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[[Category: Delatorre, P]]
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[[Category: Delatorre P]]
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[[Category: Farias, D L]]
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[[Category: Farias DL]]
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[[Category: Gadelha, C A.A]]
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[[Category: Gadelha CAA]]
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[[Category: Nagano, C S]]
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[[Category: Nagano CS]]
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[[Category: Nobrega, R B]]
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[[Category: Nobrega RB]]
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[[Category: Rocha, B A.M]]
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[[Category: Rocha BAM]]
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[[Category: Santi-Gadelha, T]]
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[[Category: Santi-Gadelha T]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Cona-like lectin]]
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Current revision

Native structure of Dioclea virgata lectin

PDB ID 3rrd

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OCA

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