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7y64
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein== | |
| - | + | <StructureSection load='7y64' size='340' side='right'caption='[[7y64]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7y64]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y64 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y64 OCA], [https://pdbe.org/7y64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y64 RCSB], [https://www.ebi.ac.uk/pdbsum/7y64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y64 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Feng YY]] | ||
| + | [[Category: Shao ZH]] | ||
| + | [[Category: Yan W]] | ||
| + | [[Category: Zhao C]] | ||
Current revision
Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
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Categories: Homo sapiens | Large Structures | Mus musculus | Feng YY | Shao ZH | Yan W | Zhao C
