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8a4a

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'''Unreleased structure'''
 
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The entry 8a4a is ON HOLD until Paper Publication
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==Structure of human Rep15 in complex with bovine Rab3C.==
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<StructureSection load='8a4a' size='340' side='right'caption='[[8a4a]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8a4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A4A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a4a OCA], [https://pdbe.org/8a4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a4a RCSB], [https://www.ebi.ac.uk/pdbsum/8a4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a4a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB3C_BOVIN RAB3C_BOVIN] Protein transport. Probably involved in vesicular traffic (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In their GTP-bound (active) form, Rab proteins interact with effector proteins that control downstream signaling. One such Rab15 effector is Rep15, which is known to have a role in receptor recycling from the endocytic recycling compartment but otherwise remains poorly characterized. Here, we report the characterization of the Rep15:Rab15 interaction and identification of Rab3 paralogs and Rab34 as Rep15 interacting partners from a yeast two-hybrid assay. Biochemical validation of the interactions is presented and crystal structures of the Rep15:Rab3B and Rep15:Rab3C complexes provide additional mechanistic insight. We find that Rep15 adopts a globular structure that is distinct from other reported Rab15, Rab3 and Rab34 effectors. Structure-based mutagenesis experiments explain the Rep15:Rab interaction specificity. Rep15 depletion in U138MG glioblastoma cells impairs cell proliferation, cell migration and receptor recycling, underscoring the need for further clarification of the role of Rep15 in cancer.
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Authors: Rai, A., Vetter, I.R., Goody, R.S.
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Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.,Rai A, Singh AK, Bleimling N, Posern G, Vetter IR, Goody RS Nat Commun. 2022 Jul 23;13(1):4262. doi: 10.1038/s41467-022-31831-1. PMID:35871249<ref>PMID:35871249</ref>
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Description: Structure of human Rep15 in complex with bovine Rab3C.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Goody, R.S]]
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<div class="pdbe-citations 8a4a" style="background-color:#fffaf0;"></div>
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[[Category: Vetter, I.R]]
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[[Category: Rai, A]]
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Goody RS]]
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[[Category: Rai A]]
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[[Category: Vetter IR]]

Current revision

Structure of human Rep15 in complex with bovine Rab3C.

PDB ID 8a4a

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