7tf7

==S. aureus GS(12) - apo==

<StructureSection load='7tf7' size='340' side='right'caption='[[7tf7]], [[Resolution|resolution]] 2.13&Aring;' scene=''>

<table><tr><td colspan='2'>[[7tf7]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TF7 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.13&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tf7 OCA], [https://pdbe.org/7tf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tf7 RCSB], [https://www.ebi.ac.uk/pdbsum/7tf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tf7 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/E3VXC2_STAAU E3VXC2_STAAU] Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.[ARBA:ARBA00002161]

==See Also==

*[[Glutamine synthetase 3D structures|Glutamine synthetase 3D structures]]

[[Category: Staphylococcus aureus]]

[[Category: Travis BA]]