This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6tgw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:02, 24 January 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6tgw' size='340' side='right'caption='[[6tgw]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='6tgw' size='340' side='right'caption='[[6tgw]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6tgw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TGW FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6tgw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TGW FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N98:methyl+5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate'>N98</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5fhz|5fhz]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N98:methyl+5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate'>N98</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALDH1A3, ALDH6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tgw OCA], [https://pdbe.org/6tgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tgw RCSB], [https://www.ebi.ac.uk/pdbsum/6tgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tgw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tgw OCA], [https://pdbe.org/6tgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tgw RCSB], [https://www.ebi.ac.uk/pdbsum/6tgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tgw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN]] Isolated anophthalmia - microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Isolated anophthalmia - microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN]] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
+
[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Retinal dehydrogenase]]
+
[[Category: Garavaglia S]]
-
[[Category: Garavaglia, S]]
+
[[Category: Rizzi M]]
-
[[Category: Rizzi, M]]
+
-
[[Category: Aldehyde dehydrogenase aldh inhibitor cancer stem cell]]
+
-
[[Category: Aldh1a3]]
+
-
[[Category: Glioblastoma mesenchymal stem cell stem cell]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor

PDB ID 6tgw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6tgw"
Personal tools