7t5y
From Proteopedia
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<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]], [[Resolution|resolution]] 2.62Å' scene=''> | <StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]], [[Resolution|resolution]] 2.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2D:3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one'>F2D</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2D:3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one'>F2D</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/PYRD_ECOLI PYRD_ECOLI]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.<ref>PMID:10074342</ref> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies. | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]] | |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ambarian | + | [[Category: Ambarian JA]] |
| - | [[Category: Davis | + | [[Category: Davis KM]] |
| - | [[Category: Horwitz | + | [[Category: Horwitz SM]] |
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Current revision
E. coli dihydroorotate dehydrogenase bound to the inhibitor HMNQ
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