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7wsz

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Current revision (17:44, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7wsz' size='340' side='right'caption='[[7wsz]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
<StructureSection load='7wsz' size='340' side='right'caption='[[7wsz]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7wsz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WSZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7wsz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WSZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wsz OCA], [https://pdbe.org/7wsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wsz RCSB], [https://www.ebi.ac.uk/pdbsum/7wsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wsz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wsz OCA], [https://pdbe.org/7wsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wsz RCSB], [https://www.ebi.ac.uk/pdbsum/7wsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wsz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
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[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7wsz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7wsz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glyoxalase 3D structures|Glyoxalase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lactoylglutathione lyase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ando, K]]
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[[Category: Ando K]]
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[[Category: Usami, M]]
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[[Category: Usami M]]
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[[Category: Yokoyama, H]]
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[[Category: Yokoyama H]]
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[[Category: Glyoxalase i]]
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[[Category: Lyase]]
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[[Category: Zinc metalloenzyme]]
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Current revision

human glyoxalase I (with C-ter His tag) in glycerol-bound form

PDB ID 7wsz

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OCA

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