3soe

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Current revision (13:03, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3soe' size='340' side='right'caption='[[3soe]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3soe' size='340' side='right'caption='[[3soe]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3soe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3soe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1634, MAGI3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3soe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3soe OCA], [https://pdbe.org/3soe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3soe RCSB], [https://www.ebi.ac.uk/pdbsum/3soe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3soe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3soe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3soe OCA], [https://pdbe.org/3soe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3soe RCSB], [https://www.ebi.ac.uk/pdbsum/3soe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3soe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MAGI3_HUMAN MAGI3_HUMAN]] Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.<ref>PMID:10748157</ref>
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[https://www.uniprot.org/uniprot/MAGI3_HUMAN MAGI3_HUMAN] Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.<ref>PMID:10748157</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P]]
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[[Category: Ivarsson Y]]
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[[Category: Ivarsson, Y]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Picaud S]]
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[[Category: Picaud, S]]
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[[Category: Vollmar M]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Vollmar, M]]
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[[Category: Zimmermann P]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Zimmermann, P]]
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[[Category: Pdz domain]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the 3rd PDZ domain of the human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI3)

PDB ID 3soe

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OCA

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